.Pharmacolibrary.Drugs.ATC.C.C08DA01

Information

Verapamil is a calcium channel blocker used therapeutically to treat hypertension, angina pectoris, and certain arrhythmias such as supraventricular tachycardia. It is approved for use and remains in clinical use today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers following a single oral dose of verapamil.

References

1. Hill, K, et al., & Sood, MM (2022). Amiodarone, Verapamil, or Diltiazem Use With Direct Oral Anticoagulants and the Risk of Hemorrhage in Older Adults. CJC open 4(3) 315–323. DOI:10.1016/j.cjco.2021.11.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35386137

2. Pham, P, et al., & Brown, JD (2020). Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function. JAMA network open 3(4) e203593–None. DOI:10.1001/jamanetworkopen.2020.3593 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32329770

3. Fuenmayor, NT, et al., & Cubeddu, LX (1992). Comparative efficacy, safety and pharmacokinetics of verapamil SR vs verapamil IR in hypertensive patients. Drugs 44 Suppl 1 1–11. DOI:10.2165/00003495-199200441-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1283570

Revisions

• 06/2025 initial generated model