.Pharmacolibrary.Drugs.ATC.C.C09BA02

Information

Combination medication containing enalapril (an angiotensin-converting enzyme inhibitor) and a diuretic, typically used in the treatment of hypertension and heart failure. Enalapril decreases blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, while the diuretic promotes sodium and water excretion. The combination is approved and used in clinical practice for patients not adequately controlled with monotherapy.

Pharmacokinetics

Pharmacokinetic parameters estimated from published data on enalapril combined with hydrochlorothiazide, for healthy adult subjects following oral administration.

References

1. Langtry, HD, & Markham, A (1997). Lisinopril. A review of its pharmacology and clinical efficacy in elderly patients. Drugs & aging 10(2) 131–166. DOI:10.2165/00002512-199710020-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9061270

2. McCormack, PL, & Wagstaff, AJ (2003). Lacidipine: a review of its use in the management of hypertension. Drugs 63(21) 2327–2356. DOI:10.2165/00003495-200363210-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14524737

3. Thabet, Y, et al., & Breitkreutz, J (2018). Continuous manufacturing and analytical characterization of fixed-dose, multilayer orodispersible films. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 117 236–244. DOI:10.1016/j.ejps.2018.02.030 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29499348

Revisions

• 06/2025 initial generated model