.Pharmacolibrary.Drugs.ATC.C.C09DA07 .Pharmacolibrary.Drugs.ATC.C.C09DA07| name: | TelmisartanAndDiuretics |
| ATC code: | C09DA07 | route: | oral |
| n-compartments | 2 |
Combination product containing telmisartan, an angiotensin II receptor antagonist, and hydrochlorothiazide, a thiazide diuretic, used for the management of hypertension in adults. Approved and in use today for lowering blood pressure and reducing cardiovascular risk.
Estimated pharmacokinetic parameters for a typical adult patient (no sex difference assumed) receiving oral telmisartan 80 mg and hydrochlorothiazide 25 mg, based on single-dose studies of each component and population PK literature for the combination, as no explicit published PK model for the combination exists.
Goebel, M, et al., & Unger, T (2006). Effective treatment of hypertension by AT(1) receptor antagonism: the past and future of telmisartan. Expert review of cardiovascular therapy 4(5) 615–629. DOI:10.1586/14779072.4.5.615 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17081084
Hu, M, et al., & Wang, X (2025). Bioequivalence and Food Effect Assessment of Two Fixed-Dose Combination Formulations of Telmisartan-Hydrochlorothiazide Tablets in Chinese Healthy Subjects. Clinical and translational science 18(5) e70228–None. DOI:10.1111/cts.70228 PUBMED:https://pubmed.ncbi.nlm.nih.gov/40279189