.Pharmacolibrary.Drugs.ATC.C.C10AA05 .Pharmacolibrary.Drugs.ATC.C.C10AA05| name: | Atorvastatin |
| ATC code: | C10AA05 | route: | oral |
| n-compartments | 2 |
Atorvastatin is a lipid-lowering medication (statin) used to prevent cardiovascular disease and to treat abnormal lipid levels. It works by inhibiting HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. Atorvastatin is approved and widely used for lowering high cholesterol and reducing risk of heart attacks and strokes.
Pharmacokinetic parameters have been reported for healthy adult volunteers after single 10 mg oral dose of atorvastatin.
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Knebel, W, et al., & Gandelman, K (2013). Population pharmacokinetics of atorvastatin and its active metabolites in children and adolescents with heterozygous familial hypercholesterolemia: selective use of informative prior distributions from adults. Journal of clinical pharmacology 53(5) 505–516. DOI:10.1002/jcph.66 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23381936
Narwal, R, et al., & Rosenbaum, SE (2010). Development of a population pharmacokinetic model for atorvastatin acid and its lactone metabolite. Clinical pharmacokinetics 49(10) 693–702. DOI:10.2165/11535980-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20818835