name: | Cerivastatin |
ATC code: | C10AA06 | route: | oral |
n-compartments | 2 |
Cerivastatin is a synthetic lipid-lowering agent of the statin class, formerly used for the treatment of hypercholesterolemia and prevention of cardiovascular disease. It acts as an HMG-CoA reductase inhibitor to decrease cholesterol synthesis in the liver. Cerivastatin was withdrawn from the market in 2001 due to reports of fatal rhabdomyolysis.
Adult healthy volunteers, single oral dose pharmacokinetics.
Mück, W (2000). Clinical pharmacokinetics of cerivastatin. Clinical pharmacokinetics 39(2) 99–116. DOI:10.2165/00003088-200039020-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10976657
Mück, W, et al., & Ahr, G (1998). Inter-ethnic comparisons of the pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. British journal of clinical pharmacology 45(6) 583–590. DOI:10.1046/j.1365-2125.1998.00717.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/9663814
Mück, W (1998). Rational assessment of the interaction profile of cerivastatin supports its low propensity for drug interactions. Drugs 56 Suppl 1 15–33. DOI:10.2165/00003495-199856001-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9740537