.Pharmacolibrary.Drugs.ATC.C.C10BX21 .Pharmacolibrary.Drugs.ATC.C.C10BX21| name: | RosuvastatinAndPerindopril |
| ATC code: | C10BX21 | route: | oral |
| n-compartments | 1 |
Rosuvastatin and perindopril is a fixed combination antihypertensive and lipid-lowering medication. Rosuvastatin is an HMG-CoA reductase inhibitor (statin) primarily used for lowering cholesterol and preventing cardiovascular disease. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor used for treating high blood pressure and heart failure. The combination is approved for cardiovascular risk reduction in selected adult patients.
No published pharmacokinetic models reporting population PK parameters for the fixed combination of rosuvastatin and perindopril with ATC code C10BX21 in humans. Individual component PK parameters are established: rosuvastatin is well-absorbed orally (bioavailability ~0.20), with a Tlag around 10 min, one-compartment model, central Vd 50 L, oral clearance approx 20 L/h; perindopril is well-absorbed, rapidly converted to active perindoprilat (bioavailability ~0.65), central Vd approx 75 L, clearance ~17 L/h. Estimates below based on published individual drug PK studies in adults after oral administration.