.Pharmacolibrary.Drugs.ATC.D.D01AC08

Information

Ketoconazole is an imidazole antifungal medication used primarily for the treatment of fungal infections of the skin and mucous membranes, such as dermatophytosis and candidiasis. It was previously used as an oral systemic antifungal agent, but its systemic use is now limited in many countries because of concerns over hepatotoxicity. Ketoconazole is still approved and widely used topically in formulations such as creams and shampoos.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers following single oral dosing.

References

1. David, OJ, et al., & Schmouder, RL (2012). Clinical pharmacokinetics of fingolimod. Clinical pharmacokinetics 51(1) 15–28. DOI:10.2165/11596550-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22149256

2. Harris, RZ, et al., & Padhi, D (2007). Pharmacokinetics of cinacalcet hydrochloride when administered with ketoconazole. Clinical pharmacokinetics 46(6) 495–501. DOI:10.2165/00003088-200746060-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17518508

3. Noh, YH, et al., & Bae, KS (2012). Effects of ketoconazole and rifampicin on the pharmacokinetics of gemigliptin, a dipeptidyl peptidase-IV inhibitor: a crossover drug-drug interaction study in healthy male Korean volunteers. Clinical therapeutics 34(5) 1182–1194. DOI:10.1016/j.clinthera.2012.04.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22534255

Revisions

• 06/2025 initial generated model