.Pharmacolibrary.Drugs.ATC.D.D02BB01 .Pharmacolibrary.Drugs.ATC.D.D02BB01| name: | Betacarotene | |
| ATC code: | D02BB01 | route: | oral |
| compartments: | 1 | |
| dosage: | 15 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0.005 | L/min |
| other parameters in model implementation | ||
Betacarotene is a provitamin A carotenoid, an antioxidant compound used primarily as a dietary supplement to prevent vitamin A deficiency and related disorders. It is not approved as a primary therapeutic agent for any disease, but is widely used in dermatology, ophthalmology, and as a nutritional supplement.
Estimated pharmacokinetic parameters for healthy adult individuals after oral administration, as direct human PK models for betacarotene are not systematically reported in published literature.
Woutersen, RA, et al., & Feron, VJ (1999). Safety evaluation of synthetic beta-carotene. Critical reviews in toxicology 29(6) 515–542. DOI:10.1080/10408449991349267 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10628775
Newcomb, SA, et al., & Davis, TP (1990). Endogenous levels of beta-carotene in human buccal mucosa cells by reversed-phase high-performance liquid chromatography. Journal of chromatography 526(1) 47–58. DOI:10.1016/s0378-4347(00)82482-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2341545