.Pharmacolibrary.Drugs.ATC.D.D04AA32 .Pharmacolibrary.Drugs.ATC.D.D04AA32| name: | Diphenhydramine |
| ATC code: | D04AA32 | route: | oral |
| n-compartments | 2 |
Diphenhydramine is a first-generation antihistamine, commonly used for the relief of allergic symptoms such as runny nose, sneezing, itching, and urticaria. It is also utilized as a short-term treatment for insomnia, motion sickness, and as an antiemetic. Diphenhydramine is approved and widely used today, though often replaced by newer, non-sedating antihistamines for allergy.
Pharmacokinetics in healthy adults, both sexes, after single oral administration.
Luna, BG, et al., & Greenblatt, DJ (1989). Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives. Journal of clinical pharmacology 29(3) 257–260. DOI:10.1002/j.1552-4604.1989.tb03323.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/2723113
Spector, R, et al., & Ghoneim, MM (1980). Diphenhydramine in Orientals and Caucasians. Clinical pharmacology and therapeutics 28(2) 229–234. DOI:10.1038/clpt.1980.155 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7398190
Paton, DM, & Webster, DR (1985). Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clinical pharmacokinetics 10(6) 477–497. DOI:10.2165/00003088-198510060-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2866055