.Pharmacolibrary.Drugs.ATC.D.D06AX02

Information

Chloramphenicol is a broad-spectrum antibiotic effective against a variety of Gram-positive and Gram-negative bacteria. It is used for the treatment of serious infections such as typhoid fever, meningitis, and rickettsial diseases, but its use has declined due to serious adverse effects (notably aplastic anemia). It is not a first-line antibiotic in most countries today and is restricted for specific indications.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after oral and intravenous administration.

References

1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

3. Ogutu, BR, et al., & Kokwaro, GO (2002). Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. British journal of clinical pharmacology 54(6) 635–642. DOI:10.1046/j.1365-2125.2002.01689.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12492612

Revisions

• 06/2025 initial generated model