name: | Chloramphenicol_1 |
ATC code: | D06AX02_1 | route: | oral |
n-compartments | 1 |
Chloramphenicol is a broad-spectrum antibiotic effective against a variety of Gram-positive and Gram-negative bacteria. It is used for the treatment of serious infections such as typhoid fever, meningitis, and rickettsial diseases, but its use has declined due to serious adverse effects (notably aplastic anemia). It is not a first-line antibiotic in most countries today and is restricted for specific indications.
Pharmacokinetic parameters in healthy adult volunteers after oral administration.
Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866
Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982
Lugo Goytia, G, et al., & Mejía, CL (2000). Relationship between clinical and biologic variables and chloramphenicol pharmacokinetic parameters in pediatric patients with sepsis. The Annals of pharmacotherapy 34(3) 393–397. DOI:10.1345/aph.19050 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10917389