.Pharmacolibrary.Drugs.ATC.D.D07AA03 .Pharmacolibrary.Drugs.ATC.D.D07AA03| name: | Prednisolone | |
| ATC code: | D07AA03 | route: | oral |
| compartments: | 2 | |
| dosage: | 20 | mg |
| volume of distribution: | 0.57 | L |
| clearance: | 239 | ml/h/kg |
| other parameters in model implementation | ||
Prednisolone is a synthetic glucocorticoid corticosteroid drug used primarily as an anti-inflammatory and immunosuppressant in the treatment of numerous conditions such as autoimmune diseases, allergies, asthma, and as replacement therapy in adrenal insufficiency. It is widely approved and used in clinical practice today.
Pharmacokinetics reported in healthy adult volunteers after oral administration.
de Truchis, C, et al., & Boyer, O (2023). Prednisolone pharmacokinetics after oral prednisone administration in paediatric patients with kidney transplant. British journal of clinical pharmacology 89(5) 1532–1540. DOI:10.1111/bcp.15610 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36510685
Petersen, KB, et al., & Schmiegelow, K (2003). Population pharmacokinetics of prednisolone in children with acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology 51(6) 465–473. DOI:10.1007/s00280-003-0602-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12698270
Yoshida, K, et al., & Chanu, P (2021). Population Pharmacokinetics of Ipatasertib and Its Metabolite in Cancer Patients. Journal of clinical pharmacology 61(12) 1579–1591. DOI:10.1002/jcph.1942 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34273118