.Pharmacolibrary.Drugs.ATC.D.D08AL30

Information

name:Silver
ATC code:D08AL30
route:topical
n-compartments1

Silver is a chemical element that has been used historically in medicine for its antimicrobial properties. Systemic use is largely obsolete due to concerns of toxicity. Today, silver is primarily used topically in the form of silver sulfadiazine or silver nitrate for burns and wound dressings. Silver and its compounds are not approved for systemic use in most countries.

Pharmacokinetics

No peer-reviewed publication has been found that reports quantitative pharmacokinetic models or parameters for elemental silver (ATC code D08AL30) in humans. Most use cases are topical, and systemic absorption is negligible or highly variable and not formally characterized.

References

  1. Ellenikiotis, H, et al., & Milgrom, P (2022). Pharmacokinetics of 38 Percent Silver Diamine Fluoride in Children. Pediatric dentistry 44(2) 114–121. PUBMED:https://pubmed.ncbi.nlm.nih.gov/35484770

  2. Chen, KF, et al., & Lin, YS (2020). Silver Diamine Fluoride in Children Using Physiologically Based PK Modeling. Journal of dental research 99(8) 907–913. DOI:10.1177/0022034520917368 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32374712

  3. Walenga, RL, et al., & Roy, P (2024). Use of the Same Model or Modeling Strategy Across Multiple Submissions: Focus on Complex Drug Products. The AAPS journal 26(1) 12–None. DOI:10.1208/s12248-023-00879-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38177638

Revisions


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