.Pharmacolibrary.Drugs.ATC.D.D09AA07 .Pharmacolibrary.Drugs.ATC.D.D09AA07| name: | Cetylpyridinium | |
| ATC code: | D09AA07 | route: | oral |
| compartments: | 1 | |
| dosage: | 1.5 | mg |
| volume of distribution: | 3 | L |
| clearance: | 0.6 | L/h/kg |
| other parameters in model implementation | ||
Cetylpyridinium is a quaternary ammonium compound with antiseptic properties, typically used in oral hygiene products such as lozenges and mouthwashes for its antibacterial activity. It is not systemically administered and not approved as a systemic drug therapy.
Estimated pharmacokinetic parameters for hypothetical systemic administration, as no referenced studies reporting PK parameters in humans are available. Cetylpyridinium is almost exclusively used topically/orally as a mouthwash or lozenge.
Matsuo, K, et al., & Van Meerbeek, B (2019). Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite. Acta biomaterialia 100 388–397. DOI:10.1016/j.actbio.2019.09.045 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31568874
Kozak, KM, et al., & White, DJ (2005). Efficacy of a high bioavailable cetylpyridinium chloride mouthrinse over a 24-hour period: a plaque imaging study. American journal of dentistry 18 Spec No 18A–23A. PUBMED:https://pubmed.ncbi.nlm.nih.gov/16178132