.Pharmacolibrary.Drugs.ATC.D.D10AA02

Information

Methylprednisolone is a synthetic glucocorticoid used primarily as an anti-inflammatory and immunosuppressant. It is indicated for a broad range of conditions, including allergies, asthma, autoimmune diseases, and certain types of arthritis. It is approved and widely used in clinical medicine.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after a single intravenous bolus. Both male and female subjects included, age range 18-45, with normal renal and hepatic function.

References

1. Barth, J, et al., & Möllenhoff, G (2004). Population pharmacokinetics of methylprednisolone in accident victims with spinal cord injury. International journal of clinical pharmacology and therapeutics 42(9) 504–511. DOI:10.5414/cpp42504 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15487809

2. Hornik, CP, et al., & Cohen-Wolkowiez, M (2019). Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass. CPT: pharmacometrics & systems pharmacology 8(12) 913–922. DOI:10.1002/psp4.12470 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31646767

3. Fokkink, WJR, et al., & Jacobs, BC (2022). Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain-Barré Syndrome. Clinical pharmacokinetics 61(9) 1285–1296. DOI:10.1007/s40262-022-01136-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/35781631

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)