name: | Methylprednisolone |
ATC code: | D10AA02 | route: | intravenous |
n-compartments | 2 |
Methylprednisolone is a synthetic glucocorticoid used primarily as an anti-inflammatory and immunosuppressant. It is indicated for a broad range of conditions, including allergies, asthma, autoimmune diseases, and certain types of arthritis. It is approved and widely used in clinical medicine.
Pharmacokinetic parameters in healthy adult volunteers after a single intravenous bolus. Both male and female subjects included, age range 18-45, with normal renal and hepatic function.
Barth, J, et al., & Möllenhoff, G (2004). Population pharmacokinetics of methylprednisolone in accident victims with spinal cord injury. International journal of clinical pharmacology and therapeutics 42(9) 504–511. DOI:10.5414/cpp42504 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15487809
Hornik, CP, et al., & Cohen-Wolkowiez, M (2019). Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass. CPT: pharmacometrics & systems pharmacology 8(12) 913–922. DOI:10.1002/psp4.12470 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31646767
Fokkink, WJR, et al., & Jacobs, BC (2022). Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain-Barré Syndrome. Clinical pharmacokinetics 61(9) 1285–1296. DOI:10.1007/s40262-022-01136-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/35781631