.Pharmacolibrary.Drugs.ATC.D.D10AD04 .Pharmacolibrary.Drugs.ATC.D.D10AD04| name: | Isotretinoin |
| ATC code: | D10AD04 | route: | oral |
| n-compartments | 1 |
Isotretinoin is a retinoid, a derivative of vitamin A, used primarily for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies. It is an oral medication approved and in use today under strict monitoring programs due to its teratogenicity and other risks.
Pharmacokinetic parameters reported for healthy adult volunteers (mostly male, age 18-35) following a single oral dose during fasting conditions.
Stotland, M, et al., & Kissling, RF (2009). Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. American journal of clinical dermatology 10(4) 221–227. DOI:10.2165/00128071-200910040-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19489655