.Pharmacolibrary.Drugs.ATC.D.D11AX05

Information

Magnesium sulfate is an inorganic salt used primarily for its anticonvulsant properties in eclampsia and pre-eclampsia, as a tocolytic agent in preterm labor, and as a replacement therapy for hypomagnesemia. It is also used intravenously or intramuscularly for the management of arrhythmias and severe asthma exacerbations. Approved for medical use, especially in obstetric and emergency medicine settings.

Pharmacokinetics

Pharmacokinetic parameters reported in adult patients (including pregnant women) following intravenous administration; typically referenced from published population PK studies in critically ill patients.

References

1. da Costa, TX, et al., & Oliveira, AG (2020). Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors. Drugs in R&D 20(3) 257–266. DOI:10.1007/s40268-020-00315-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32642964

2. Brookfield, KF, et al., & Carvalho, B (2016). Pharmacokinetics and placental transfer of magnesium sulfate in pregnant women. American journal of obstetrics and gynecology 214(6) 737.e1–737.e7379. DOI:10.1016/j.ajog.2015.12.060 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26767791

3. Rower, JE, et al., & Finkelstein, Y (2025). Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. Journal of clinical pharmacology 65(6) 665–674. DOI:10.1002/jcph.6179 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39775569

Revisions

• 06/2025 initial generated model