.Pharmacolibrary.Drugs.ATC.D.D11AX10 .Pharmacolibrary.Drugs.ATC.D.D11AX10| name: | Finasteride |
| ATC code: | D11AX10 | route: | oral |
| n-compartments | 1 |
Finasteride is a 5-alpha-reductase inhibitor used primarily to treat benign prostatic hyperplasia (BPH) and male pattern hair loss (androgenetic alopecia). It blocks the conversion of testosterone to dihydrotestosterone (DHT), a key factor in prostate enlargement and hair follicle miniaturization. Finasteride is an approved prescription medication, used today for these indications, mainly in adult males.
Pharmacokinetic parameters reported from healthy adult male volunteers after single oral dose administration.
Roth, MY, et al., & Amory, JK (2011). Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5α-reductase by finasteride. International journal of andrology 34(6 Pt 1) 541–547. DOI:10.1111/j.1365-2605.2010.01120.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/20969601
Yasumori, T, et al., & Taniguchi, T (2006). Finasteride 1 mg has no inhibitory effect on omeprazole metabolism in extensive and poor metabolizers for CYP2C19 in Japanese. European journal of clinical pharmacology 62(11) 939–946. DOI:10.1007/s00228-006-0189-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16953457