.Pharmacolibrary.Drugs.ATC.D.D11AX21

Information

name:Brimonidine
ATC code:D11AX21
route:topical
n-compartments1

Brimonidine is an alpha2-adrenergic receptor agonist primarily used for the treatment of open-angle glaucoma and ocular hypertension to reduce intraocular pressure. It is also used topically for the treatment of facial erythema of rosacea. Brimonidine is approved for use today in several countries including the US and EU.

Pharmacokinetics

Estimated pharmacokinetic values for brimonidine topical administration in adults based on available summary information and extrapolation from ocular use, as no direct published pharmacokinetic data is available for topical rosacea formulation.

References

  1. Ackerman, SL, et al., & Vittitow, JL (2019). Low-dose brimonidine for relief of ocular redness: integrated analysis of four clinical trials. Clinical & experimental optometry 102(2) 131–139. DOI:10.1111/cxo.12846 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30525235

  2. Kim, CY, et al., & Seong, GJ (2007). Brimonidine 0.2% versus brimonidine Purite 0.15% in Asian ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 23(5) 481–486. DOI:10.1089/jop.2007.0042 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17900227

  3. Durairaj, C, et al., & Cherukury, M (2014). Mechanism - based translational pharmacokinetic - pharmacodynamic model to predict intraocular pressure lowering effect of drugs in patients with glaucoma or ocular hypertension. Pharmaceutical research 31(8) 2095–2106. DOI:10.1007/s11095-014-1311-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24549827

Revisions


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