.Pharmacolibrary.Drugs.ATC.D.D11AX27 .Pharmacolibrary.Drugs.ATC.D.D11AX27| name: | Oxymetazoline |
| ATC code: | D11AX27 | route: | topical |
| n-compartments | 1 |
Oxymetazoline is an imidazoline derivative acting as a selective alpha-1 adrenergic receptor agonist and partial alpha-2 agonist, used primarily as a topical decongestant for nasal congestion and, more recently, in topical creams for rosacea and eye drops for redness. It is approved for current clinical use as a nasal spray, ophthalmic solution, and topical dermatological preparation.
Pharmacokinetic parameters estimated for a typical adult after topical (cutaneous) administration; no specific published human PK data found for this cutaneous route. Values are estimated from related nasal/ophthalmic human data and animal data, extrapolated for cutaneous application.
Kuang, AW, et al., & Ahluwalia, G (2018). Clinical Pharmacokinetics of Oxymetazoline Cream Following Topical Facial Administration for the Treatment of Erythema Associated With Rosacea. Journal of drugs in dermatology : JDD 17(2) 213–220. PUBMED:https://pubmed.ncbi.nlm.nih.gov/29462230
Cartabuke, R, et al., & Jatana, KR (2021). Topical Nasal Decongestant Oxymetazoline: Safety Considerations for Perioperative Pediatric Use. Pediatrics 148(5) –. DOI:10.1542/peds.2021-054271 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34607935
Cartabuke, RS, et al., & Tobias, JD (2019). Hemodynamic and pharmacokinetic analysis of oxymetazoline use during nasal surgery in children. The Laryngoscope 129(12) 2775–2781. DOI:10.1002/lary.27760 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30786035