.Pharmacolibrary.Drugs.ATC.G.G01AA05

Information

Chloramphenicol is a broad-spectrum antibiotic that was historically used to treat a wide range of bacterial infections, including typhoid fever, meningitis, and eye infections. Due to serious adverse effects such as aplastic anemia and bone marrow suppression, its use is now restricted or avoided in many countries, reserved mainly for severe infections when alternative antibiotics are ineffective or contraindicated.

Pharmacokinetics

Pharmacokinetic parameters obtained from healthy adult volunteers following oral and intravenous administration.

References

1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

3. Ogutu, BR, et al., & Kokwaro, GO (2002). Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. British journal of clinical pharmacology 54(6) 635–642. DOI:10.1046/j.1365-2125.2002.01689.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/12492612

Revisions

• 06/2025 initial generated model