.Pharmacolibrary.Drugs.ATC.G.G01AA05_1

Information

Chloramphenicol is a broad-spectrum antibiotic that was historically used to treat a wide range of bacterial infections, including typhoid fever, meningitis, and eye infections. Due to serious adverse effects such as aplastic anemia and bone marrow suppression, its use is now restricted or avoided in many countries, reserved mainly for severe infections when alternative antibiotics are ineffective or contraindicated.

Pharmacokinetics

Parameters estimated for oral administration in healthy adults.

References

1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

3. Lugo Goytia, G, et al., & Mejía, CL (2000). Relationship between clinical and biologic variables and chloramphenicol pharmacokinetic parameters in pediatric patients with sepsis. The Annals of pharmacotherapy 34(3) 393–397. DOI:10.1345/aph.19050 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10917389

Revisions

• 06/2025 initial generated model