.Pharmacolibrary.Drugs.ATC.G.G01AD01

Information

Lactic acid is an organic acid that occurs naturally in the body as a product of anaerobic glycolysis, but is also used pharmaceutically as a topical agent. It is present in over-the-counter preparations for vaginal disorders such as bacterial vaginosis, often in the form of vaginal tablets, gels, or douches. It is not a systemically acting drug and is not intended for oral or parenteral administration. Lactic acid (G01AD01) is approved for local treatment of vaginal infections and disorders related to pH imbalance.

Pharmacokinetics

No pharmacokinetic models or compartment-based PK parameters for lactic acid when administered intravaginally were identified in the published literature. As lactic acid is a physiologic metabolite and used topically, systemic absorption is minimal and generally not quantified.

References

1. Mohideen, M, et al., & Saltzman, WM (2017). Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. Biomaterials 144 144–154. DOI:10.1016/j.biomaterials.2017.08.029 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28829952

Revisions

• 06/2025 initial generated model