.Pharmacolibrary.Drugs.ATC.G.G01AG02 .Pharmacolibrary.Drugs.ATC.G.G01AG02| name: | Terconazole | |
| ATC code: | G01AG02 | route: | intravaginal |
| compartments: | 1 | |
| dosage: | 80 | mg |
| volume of distribution: | 6.6 | L |
| clearance: | 70 | L/h |
| other parameters in model implementation | ||
Terconazole is a triazole antifungal agent primarily used for the treatment of vulvovaginal candidiasis. It is administered as a topical formulation and is FDA-approved for intravaginal use. Its mechanism of action is through inhibition of fungal cytochrome P450 14α-demethylase, impairing ergosterol synthesis and thus fungal cell membrane formation.
Pharmacokinetic parameters estimated for adult female subjects using intravaginal administration; values are approximated based on summary statements available from product labels and secondary literature, as no detailed compartmental PK modeling for terconazole in humans is published.