.Pharmacolibrary.Drugs.ATC.G.G03FA11

Information

name:LevonorgestrelAndEstrogen
ATC code:G03FA11
route:oral
n-compartments2

Levonorgestrel and estrogen (commonly ethinylestradiol) combination is widely used as an oral contraceptive for the prevention of pregnancy. This combination is approved and used globally for birth control in women of reproductive age, as well as for management of menstrual disorders and hormone replacement therapy in some contexts.

Pharmacokinetics

Estimated pharmacokinetic parameters for healthy adult women following a single oral dose of levonorgestrel (0.15 mg) and ethinylestradiol (0.03 mg). Data is generalized from published literature on combined oral contraceptive formulations, as direct clinical PK parameters for this exact combination (G03FA11) are sparse.

References

  1. Adedoyin, A, et al., & Iwamoto, M (2019). Effect of letermovir on levonorgestrel and ethinyl estradiol pharmacokinetics
. International journal of clinical pharmacology and therapeutics 57(9) 450–457. DOI:10.5414/CP203483 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31232280

  2. Kanarkowski, R, et al., & Jusko, WJ (1988). Pharmacokinetics of single and multiple doses of ethinyl estradiol and levonorgestrel in relation to smoking. Clinical pharmacology and therapeutics 43(1) 23–31. DOI:10.1038/clpt.1988.7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3121231

  3. Kuhnz, W (1990). Pharmacokinetics of the contraceptive steroids levonorgestrel and gestodene after single and multiple oral administration to women. American journal of obstetrics and gynecology 163(6 Pt 2) 2120–2127. DOI:10.1016/0002-9378(90)90551-h PUBMED:https://pubmed.ncbi.nlm.nih.gov/2124087

Revisions


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