.Pharmacolibrary.Drugs.ATC.G.G04BA01 .Pharmacolibrary.Drugs.ATC.G.G04BA01| name: | AmmoniumChloride | |
| ATC code: | G04BA01 | route: | oral |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 0.6 | L |
| clearance: | 6 | L/h |
| other parameters in model implementation | ||
Ammonium chloride is an inorganic compound used historically as an expectorant in cough medicine and as a systemic acidifying agent in the treatment of metabolic alkalosis. It is also used to increase urinary acidity for certain medical conditions. Its routine use as a medication is not common in modern clinical practice, and it is not widely approved for therapeutic use globally today.
Estimated pharmacokinetic parameters for healthy adult humans, as published PK models or direct clinical pharmacokinetic data for ammonium chloride are not available.
Liu, R, et al., & Lee, EJ (2011). Effects of sodium bicarbonate and ammonium chloride pre-treatments on PEPT2 (SLC15A2) mediated renal clearance of cephalexin in healthy subjects. Drug metabolism and pharmacokinetics 26(1) 87–93. DOI:10.2133/dmpk.dmpk-10-rg-039 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21084767