name: | Papaverine_1 |
ATC code: | G04BE02_1 | route: | oral |
n-compartments | 1 |
Papaverine is an opium alkaloid antispasmodic drug used primarily to treat visceral spasm, vasospasm (including cerebral vasospasm after subarachnoid hemorrhage), and sometimes erectile dysfunction. While it was historically used for gastrointestinal spasms, its clinical use has declined due to the availability of safer alternatives, but it is still approved for some indications.
Pharmacokinetics after oral administration in healthy adult volunteers; oral absorption assumed with first-order kinetics.
Porst, H, et al., & Sharlip, I (2013). SOP conservative (medical and mechanical) treatment of erectile dysfunction. The journal of sexual medicine 10(1) 130–171. DOI:10.1111/jsm.12023 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23343170
Yamamoto, H, et al., & Sugano, K (2023). Application of Population Balance Model to Simulate Precipitation of Weak Base and Zwitterionic Drugs in Gastrointestinal pH Environment. Molecular pharmaceutics 20(4) 2266–2275. DOI:10.1021/acs.molpharmaceut.3c00088 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36929729
Song, M, et al., & Yang, L (2009). Development of an LC-MS/MS method for the simultaneous quantification of aripiprazole and dehydroaripiprazole in human plasma. Analytical biochemistry 385(2) 270–277. DOI:10.1016/j.ab.2008.11.027 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19070586