.Pharmacolibrary.Drugs.ATC.G.G04BX14

Information

name:Dapoxetine
ATC code:G04BX14
route:oral
n-compartments2

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) developed specifically for the treatment of premature ejaculation in men. It is approved for this indication in several countries but not in the United States.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult male volunteers after a single oral dose (fasted state).

References

  1. Liu, J, et al., & Qiu, W (2021). Pharmacokinetics and Safety of Dapoxetine Hydrochloride in Healthy Chinese Men: Impact of Dose and High-Fat Meal. Clinical pharmacology in drug development 10(10) 1216–1224. DOI:10.1002/cpdd.919 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33528113

  2. Thyssen, A, et al., & Hsiao, HL (2010). Pharmacokinetics of dapoxetine hydrochloride in healthy Chinese, Japanese, and Caucasian men. Journal of clinical pharmacology 50(12) 1450–1460. DOI:10.1177/0091270009359183 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20097934

  3. Wang, Z, et al., & Qiu, W (2024). Effects of CYP2D6 *10 and *41 Variants in Healthy Chinese Men on the Pharmacokinetics of Dapoxetine. Journal of clinical pharmacology 64(5) 601–608. DOI:10.1002/jcph.2391 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38059315

Revisions

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