.Pharmacolibrary.Drugs.ATC.H.H01BA02_1 .Pharmacolibrary.Drugs.ATC.H.H01BA02_1| name: | Desmopressin_1 |
| ATC code: | H01BA02_1 | route: | intravenous |
| n-compartments | 1 |
Desmopressin is a synthetic analogue of the natural pituitary hormone vasopressin. It is primarily used in the treatment of diabetes insipidus, nocturnal enuresis, and certain bleeding disorders such as hemophilia A and von Willebrand's disease. The drug is approved and widely used today.
Pharmacokinetic parameters reported in healthy adult males after intravenous administration.
de Jager, NCB, et al., & Mathôt, RAA (2020). Population Pharmacokinetic Modeling of von Willebrand Factor Activity in von Willebrand Disease Patients after Desmopressin Administration. Thrombosis and haemostasis 120(10) 1407–1416. DOI:10.1055/s-0040-1714349 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32746466
Heijdra, JM, et al., & Mathôt, RAA (2022). Quantification of the relationship between desmopressin concentration and Von Willebrand factor in Von Willebrand disease type 1: A pharmacodynamic study. Haemophilia : the official journal of the World Federation of Hemophilia 28(5) 814–821. DOI:10.1111/hae.14582 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35526239
Schütte, LM, et al., & Mathôt, RAA (2018). Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients. Thrombosis and haemostasis 118(4) 621–629. DOI:10.1160/TH17-06-0390 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29458233