.Pharmacolibrary.Drugs.ATC.H.H05AA02 .Pharmacolibrary.Drugs.ATC.H.H05AA02| name: | Teriparatide |
| ATC code: | H05AA02 | route: | subcutaneous |
| n-compartments | 1 |
Teriparatide is a recombinant form of parathyroid hormone (PTH 1-34) used primarily for the treatment of osteoporosis in postmenopausal women and men at high risk for fracture. It stimulates new bone formation by acting on osteoblasts. Teriparatide is approved and widely used in clinical practice today.
Pharmacokinetic parameters following a single subcutaneous dose of 20 mcg in healthy adult volunteers (both sexes).
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Kumagai, Y, et al., & Sugimoto, T (2020). Safety Profiles, Pharmacokinetics, and Changes in Bone Turnover Markers After Twice-Weekly Subcutaneous Administration of Teriparatide in Healthy Japanese Postmenopausal Women: A Single-Blind Randomized Study. Clinical pharmacology in drug development 9(1) 87–96. DOI:10.1002/cpdd.687 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30921502
Ose, A, et al., & Tanigawara, Y (2017). Population Pharmacokinetic and Exposure-Response Analysis of Weekly Teriparatide in Osteoporosis Patients. Journal of clinical pharmacology 57(12) 1545–1553. DOI:10.1002/jcph.949 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28614613