.Pharmacolibrary.Drugs.ATC.J.J01AA12

Information

Tigecycline is a glycylcycline antibiotic structurally related to tetracyclines. It is used to treat complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia caused by susceptible organisms. It is approved for clinical use in many countries.

Pharmacokinetics

Pharmacokinetic parameters after intravenous administration in healthy adult volunteers.

References

1. Rubino, CM, et al., & Ambrose, PG (2010). Tigecycline population pharmacokinetics in patients with community- or hospital-acquired pneumonia. Antimicrobial agents and chemotherapy 54(12) 5180–5186. DOI:10.1128/AAC.01414-09 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20921315

2. Van Wart, SA, et al., & Owen, JS (2007). Population pharmacokinetics of tigecycline in healthy volunteers. Journal of clinical pharmacology 47(6) 727–737. DOI:10.1177/0091270007300263 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17519399

3. Van Wart, SA, et al., & Cirincione, BB (2006). Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections. Antimicrobial agents and chemotherapy 50(11) 3701–3707. DOI:10.1128/AAC.01636-05 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16940069

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)