.Pharmacolibrary.Drugs.ATC.J.J01AA20

Information

name:CombinationsOfTetracyclines
ATC code:J01AA20
route:oral
n-compartments1

This ATC group refers to fixed drug combinations that contain at least one tetracycline antibiotic, usually for oral use in the treatment of various bacterial infections. Such combinations were used in the past for synergy or broader antimicrobial coverage, but most are now rarely used due to resistance development and the availability of newer, more effective treatments. No specific combination product under J01AA20 is currently widely approved or in regular therapeutic use today.

Pharmacokinetics

Pharmacokinetic parameters estimated for an oral combination of tetracyclines in a typical adult population, based on known single-compound tetracycline kinetics; no direct published PK study for combination products was found.

References

  1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

  2. Pardos, SL, et al., & MacGowan, AP (2024). Population pharmacokinetics/pharmacodynamics of minocycline plus rifampicin in patients with complicated skin and skin structure infections caused by MRSA. The Journal of antimicrobial chemotherapy 79(12) 3303–3312. DOI:10.1093/jac/dkae363 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39412246

  3. Hunt, TL, et al., & McGovern, PC (2021). The Effect of Verapamil, a P-gp Inhibitor, on the Pharmacokinetics, Safety, and Tolerability of Omadacycline in Healthy Adults: A Phase I, Open-Label, Single-Sequence Study. European journal of drug metabolism and pharmacokinetics 46(1) 85–92. DOI:10.1007/s13318-020-00651-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33180250

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos