.Pharmacolibrary.Drugs.ATC.J.J01CA17 .Pharmacolibrary.Drugs.ATC.J.J01CA17| name: | Temocillin |
| ATC code: | J01CA17 | route: | intravenous |
| n-compartments | 2 |
Temocillin is a narrow-spectrum, beta-lactamase-resistant penicillin antibiotic. It is primarily used for treating infections caused by Gram-negative bacteria, including Enterobacteriaceae that produce extended-spectrum beta-lactamases (ESBLs). Temocillin is not active against Gram-positive organisms or non-fermenters like Pseudomonas aeruginosa. It is approved in some European countries but is not widely used globally.
PK parameters were determined in healthy adult volunteers after a single intravenous bolus administration.
Ngougni Pokem, P, et al., & Laterre, PF (2022). Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion. Antibiotics (Basel, Switzerland) 11(7) –. DOI:10.3390/antibiotics11070898 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35884152
De Jongh, R, et al., & Carryn, S (2008). Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection. The Journal of antimicrobial chemotherapy 61(2) 382–388. DOI:10.1093/jac/dkm467 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18070831