.Pharmacolibrary.Drugs.ATC.J.J01CE02

Information

Phenoxymethylpenicillin, also known as penicillin V, is a narrow-spectrum beta-lactam antibiotic of the penicillin class, mainly active against Gram-positive bacteria. It is approved and commonly used today for the treatment of mild to moderate infections including streptococcal pharyngitis, tonsillitis, and some dental infections, generally administered orally due to its acid stability.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after oral administration.

References

1. Rawson, TM, et al., & Holmes, AH (2021). Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study. Open forum infectious diseases 8(12) ofab573–None. DOI:10.1093/ofid/ofab573 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34934774

2. Langtry, HD, & Balfour, JA (1998). Azithromycin. A review of its use in paediatric infectious diseases. Drugs 56(2) 273–297. DOI:10.2165/00003495-199856020-00014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9711451

3. Rawson, TM, et al., & Holmes, AH (2019). Microneedle biosensors for real-time, minimally invasive drug monitoring of phenoxymethylpenicillin: a first-in-human evaluation in healthy volunteers. The Lancet. Digital health 1(7) e335–e343. DOI:10.1016/S2589-7500(19)30131-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33323208

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)