.Pharmacolibrary.Drugs.ATC.J.J01CF05_1

Information

Flucloxacillin is a beta-lactam antibiotic of the penicillin class, used for treating infections due to susceptible Gram-positive bacteria. It remains in clinical use today for various infection types.

Pharmacokinetics

Pharmacokinetic parameters in healthy adults after intravenous bolus administration.

References

1. Meenks, SD, et al., & Janssen, PKC (2023). Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study. Critical care (London, England) 27(1) 82–None. DOI:10.1186/s13054-023-04353-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36869388

2. Hermann, L, et al., & Hammann, F (2024). Population pharmacokinetics of flucloxacillin as intermittent bolus infusion in patients with Staphylococcus aureus bloodstream infection. The Journal of antimicrobial chemotherapy 79(8) 2031–2039. DOI:10.1093/jac/dkae207 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38946285

3. Öbrink-Hansen, K, et al., & Stilling, M (2022). Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue- Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations. Pharmaceutical research 39(7) 1633–1643. DOI:10.1007/s11095-022-03197-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/35233728

Revisions

• 06/2025 initial generated model