name: | Cefuroxime |
ATC code: | J01DC02 | route: | intravenous |
n-compartments | 2 |
Cefuroxime is a second-generation cephalosporin antibiotic with broad-spectrum activity against gram-positive and gram-negative bacteria. It is used to treat various infections, including respiratory tract, urinary tract, skin and soft tissue infections. Cefuroxime is approved and widely used clinically.
Pharmacokinetic parameters in healthy adult volunteers after a single intravenous dose.
Janssen, PK, et al., & le Noble, JL (2016). Population Pharmacokinetics of Cefuroxime in Critically Ill Patients Receiving Continuous Venovenous Hemofiltration With Regional Citrate Anticoagulation and a Phosphate-Containing Replacement Fluid. Therapeutic drug monitoring 38(6) 699–705. DOI:10.1097/FTD.0000000000000330 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27494946
Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866
Carlier, M, et al., & De Waele, JJ (2014). Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures. The Journal of antimicrobial chemotherapy 69(10) 2797–2803. DOI:10.1093/jac/dku195 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24917580