.Pharmacolibrary.Drugs.ATC.J.J01DC05 .Pharmacolibrary.Drugs.ATC.J.J01DC05| name: | Cefotetan |
| ATC code: | J01DC05 | route: | intravenous |
| n-compartments | 2 |
Cefotetan is a second-generation cephalosporin antibiotic used primarily in the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria, including urinary tract infections, intra-abdominal infections, and perioperative prophylaxis. It is administered parenterally and is approved for clinical use.
Pharmacokinetic parameters in healthy adult volunteers, following a single intravenous dose administration.
Liu, J, et al., & Shentu, J (2020). Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers. Drug design, development and therapy 14 613–620. DOI:10.2147/DDDT.S234619 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32103903
Yates, RA, et al., & Laws, EA (1983). Pharmacokinetics and tolerance of single intravenous doses of cefotetan disodium in male Caucasian volunteers. The Journal of antimicrobial chemotherapy 11 Suppl 185–191. DOI:10.1093/jac/11.suppl_a.185 PUBMED:https://pubmed.ncbi.nlm.nih.gov/6573315
Adam, HK, et al., & Donnelly, RJ (1983). Pharmacokinetics and tolerance of a 24-h infusion of cefotetan disodium (with and without loading dose) in normal Caucasian volunteers. The Journal of antimicrobial chemotherapy 11 Suppl 193–199. DOI:10.1093/jac/11.suppl_a.193 PUBMED:https://pubmed.ncbi.nlm.nih.gov/6573316