.Pharmacolibrary.Drugs.ATC.J.J01DH51 .Pharmacolibrary.Drugs.ATC.J.J01DH51| name: | ImipenemAndCilastatin | |
| ATC code: | J01DH51 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 500 | mg |
| volume of distribution: | 15.0 | L |
| clearance: | 10.0 | L/h |
| other parameters in model implementation | ||
Imipenem and cilastatin is a combination antibiotic approved for treatment of serious bacterial infections, particularly hospital-acquired or complicated infections caused by susceptible organisms. Imipenem is a broad-spectrum beta-lactam carbapenem antibiotic, while cilastatin is a dehydropeptidase inhibitor added to prevent the renal breakdown of imipenem and prolong its antibacterial activity.
Pharmacokinetic parameters reported for healthy adult subjects after intravenous administration.
Sakka, SG, et al., & Sörgel, F (2007). Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial. Antimicrobial agents and chemotherapy 51(9) 3304–3310. DOI:10.1128/AAC.01318-06 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17620371