.Pharmacolibrary.Drugs.ATC.J.J01FA09

Information

Clarithromycin is a macrolide antibiotic used to treat various bacterial infections including respiratory tract infections, skin infections, and Helicobacter pylori-associated peptic ulcers. It is approved and widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects following oral dosing.

References

1. Echizen, H (2016). The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations. Clinical pharmacokinetics 55(4) 409–418. DOI:10.1007/s40262-015-0326-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26369775

2. Bizjak, ED, & Mauro, VF (1997). Digoxin-macrolide drug interaction. The Annals of pharmacotherapy 31(9) 1077–1079. DOI:10.1177/106002809703100918 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9296249

3. Corrêa, JC, et al., & Yang, JY (2003). Randomized, open-label, parallel-group, multicenter study of the efficacy and tolerability of IV gatifloxacin with the option for oral stepdown gatifloxacin versus IV ceftriaxone (with or without erythromycin or clarithromycin) with the option for oral stepdown clarithromycin for treatment of patients with mild to moderate community-acquired pneumonia requiring hospitalization. Clinical therapeutics 25(5) 1453–1468. DOI:10.1016/s0149-2918(03)80132-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12867221

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)