.Pharmacolibrary.Drugs.ATC.J.J01FG02 .Pharmacolibrary.Drugs.ATC.J.J01FG02| name: | QuinupristinDalfopristin | |
| ATC code: | J01FG02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 500 | mg |
| volume of distribution: | 0.22 | L |
| clearance: | 1.2 | L/h/kg |
| other parameters in model implementation | ||
Quinupristin/dalfopristin is a combination of two streptogramin antibiotics. It acts synergistically to inhibit bacterial protein synthesis and is used primarily in the treatment of serious infections caused by multidrug-resistant Gram-positive organisms, including vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus. It is approved for clinical use in certain countries but its use has become limited due to adverse effects and availability of alternative agents.
Pharmacokinetic parameters reported in healthy adult volunteers following intravenous administration.