.Pharmacolibrary.Drugs.ATC.J.J01MA16

Information

name:Gatifloxacin
ATC code:J01MA16
route:oral
n-compartments2

Gatifloxacin is a fourth-generation fluoroquinolone antibiotic formerly used to treat a variety of bacterial infections including respiratory tract infections, urinary tract infections, and conjunctivitis. It has been withdrawn from many markets (including the US and Europe) due to concerns of dysglycemia (blood sugar disturbances), but may still be used in some countries and as an ophthalmic preparation.

Pharmacokinetics

Pharmacokinetic profile in healthy adult volunteers following a single oral 400 mg dose.

References

  1. Peloquin, CA, et al., & Johnson, JL (2008). Population pharmacokinetics of levofloxacin, gatifloxacin, and moxifloxacin in adults with pulmonary tuberculosis. Antimicrobial agents and chemotherapy 52(3) 852–857. DOI:10.1128/AAC.01036-07 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18070980

  2. Kikuchi, J, et al., & Nishimura, M (2007). Pharmacokinetics of gatifloxacin after a single oral dose in healthy young adult subjects and adult patients with chronic bronchitis, with a comparison of drug concentrations obtained by bronchoscopic microsampling and bronchoalveolar lavage. Clinical therapeutics 29(1) 123–130. DOI:10.1016/j.clinthera.2007.01.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17379052

  3. Corrêa, JC, et al., & Yang, JY (2003). Randomized, open-label, parallel-group, multicenter study of the efficacy and tolerability of IV gatifloxacin with the option for oral stepdown gatifloxacin versus IV ceftriaxone (with or without erythromycin or clarithromycin) with the option for oral stepdown clarithromycin for treatment of patients with mild to moderate community-acquired pneumonia requiring hospitalization. Clinical therapeutics 25(5) 1453–1468. DOI:10.1016/s0149-2918(03)80132-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12867221

Revisions


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