name: | Pazufloxacin |
ATC code: | J01MA18 | route: | intravenous |
n-compartments | 2 |
Pazufloxacin is a fluoroquinolone antibiotic, primarily used for the treatment of bacterial infections such as respiratory tract infections, urinary tract infections, and intra-abdominal infections. It is mainly used in Japan and some other Asian countries and is not widely approved in the US or Europe.
Pharmacokinetic parameters reported in healthy adult male volunteers after single intravenous administration.
Lee, J, et al., & Yoon, YR (2012). Single-dose pharmacokinetics and dose proportionality of intravenous pazufloxacin mesilate in healthy Korean volunteers. Expert opinion on drug metabolism & toxicology 8(8) 921–928. DOI:10.1517/17425255.2012.688951 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22809012
Oonishi, Y, et al., & Yamaguchi, K (2007). Effect of GrlA mutation on the development of quinolone resistance in Staphylococcus aureus in an in vitro pharmacokinetic model. The Journal of antimicrobial chemotherapy 60(5) 1030–1037. DOI:10.1093/jac/dkm344 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17827137