.Pharmacolibrary.Drugs.ATC.J.J01MA22

Information

name:Tosufloxacin
ATC code:J01MA22
route:oral
n-compartments1

Tosufloxacin is a fluoroquinolone antibiotic used primarily for the treatment of bacterial infections, including respiratory tract, urinary tract, and skin infections. While it has been approved and used in Japan and several Asian countries, it is not approved in Europe or the United States due to safety concerns related to toxicity.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after oral administration of a single 150 mg dose of tosufloxacin.

References

  1. Yamamoto, H, et al., & Sugano, K (2023). Application of Population Balance Model to Simulate Precipitation of Weak Base and Zwitterionic Drugs in Gastrointestinal pH Environment. Molecular pharmaceutics 20(4) 2266–2275. DOI:10.1021/acs.molpharmaceut.3c00088 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36929729

  2. Oonishi, Y, et al., & Yamaguchi, K (2007). Effect of GrlA mutation on the development of quinolone resistance in Staphylococcus aureus in an in vitro pharmacokinetic model. The Journal of antimicrobial chemotherapy 60(5) 1030–1037. DOI:10.1093/jac/dkm344 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17827137

Revisions


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