.Pharmacolibrary.Drugs.ATC.J.J01RA03 .Pharmacolibrary.Drugs.ATC.J.J01RA03| name: | CefuroximeAndMetronidazole | |
| ATC code: | J01RA03 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 1500 | mg |
| volume of distribution: | 18 | L |
| clearance: | 1200 | mL/min |
| other parameters in model implementation | ||
Cefuroxime and metronidazole (ATC code J01RA03) is a fixed-dose combination of two antimicrobial agents. Cefuroxime is a second-generation cephalosporin antibiotic effective against a range of Gram-positive and Gram-negative bacteria, mainly used for perioperative prophylaxis and treatment of various infections. Metronidazole is an antiprotozoal and antibacterial agent particularly effective against anaerobic bacteria and protozoa, widely used for intra-abdominal and gynecological infections. This combination is used to provide broad-spectrum coverage for mixed infections, including surgical prophylaxis and treatment of intra-abdominal infections. Both drugs are approved and used in clinical practice.
No published pharmacokinetic models were found for the fixed-dose cefuroxime and metronidazole combination. Instead, typical adult pharmacokinetic parameters for intravenous administration were estimated from literature for each component.
Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866