.Pharmacolibrary.Drugs.ATC.J.J01XX01

Information

Fosfomycin is a broad-spectrum antibiotic primarily used to treat uncomplicated urinary tract infections. It works by inhibiting bacterial cell wall synthesis and is effective against both Gram-positive and Gram-negative bacteria. Fosfomycin (with ATC code J01XX01) is approved for clinical use and remains in use today, particularly for treating urinary tract infections.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers following single-dose oral administration.

References

1. Isla, A, et al., & Rodríguez-Gascón, A (2024). Population pharmacokinetics of oral fosfomycin calcium in healthy women. The Journal of antimicrobial chemotherapy 79(11) 2837–2845. DOI:10.1093/jac/dkae295 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39205651

2. Kane, Z, et al., & Standing, JF (2021). IV and oral fosfomycin pharmacokinetics in neonates with suspected clinical sepsis. The Journal of antimicrobial chemotherapy 76(7) 1855–1864. DOI:10.1093/jac/dkab083 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33855449

3. Wenzler, E, et al., & Rodvold, KA (2017). Pharmacokinetics, Safety, and Tolerability of Single-Dose Intravenous (ZTI-01) and Oral Fosfomycin in Healthy Volunteers. Antimicrobial agents and chemotherapy 61(9) –. DOI:10.1128/AAC.00775-17 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28630194

Revisions

• 06/2025 initial generated model