.Pharmacolibrary.Drugs.ATC.J.J01XX08

Information

name:Linezolid
ATC code:J01XX08
route:oral
n-compartments1

Linezolid is a synthetic antibiotic of the oxazolidinone class. It is primarily used to treat infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Linezolid is approved for clinical use and commonly prescribed for pneumonia, skin and soft tissue infections, and other severe bacterial infections.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers aged 18-55 years after single and multiple dosing (oral and intravenous administration), both sexes.

References

  1. Ubals, M, et al., & Mitjà, O (2024). Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial. The Lancet. Infectious diseases 24(4) 404–416. DOI:10.1016/S1473-3099(23)00683-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38211601

  2. Bock, M, et al., & Moser, C (2023). Attainment of Target Antibiotic Levels by Oral Treatment of Left-Sided Infective Endocarditis: A POET Substudy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 77(2) 242–251. DOI:10.1093/cid/ciad168 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36947131

  3. Sicard, M, et al., & Guen, CG (2015). Pharmacokinetics of linezolid treatment using intravenous and oral administrations in extremely premature infants. European journal of clinical pharmacology 71(5) 611–615. DOI:10.1007/s00228-015-1813-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25740677

Revisions


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