.Pharmacolibrary.Drugs.ATC.J.J02AX01

Information

name:Flucytosine
ATC code:J02AX01
route:oral
n-compartments1

Flucytosine is an antifungal medication used primarily in combination with other agents (commonly amphotericin B) for the treatment of severe systemic fungal infections such as cryptococcal meningitis and candidiasis. It acts as a pyrimidine analog, interfering with fungal DNA and RNA synthesis. Flucytosine is approved by regulatory agencies and remains in use today, mainly for specific difficult-to-treat infections and susceptible organisms.

Pharmacokinetics

Pharmacokinetic data for orally administered flucytosine in adult patients with normal renal function.

References

  1. Kim, HY, et al., & Alffenaar, JW (2020). Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review. Frontiers in pharmacology 11 894–None. DOI:10.3389/fphar.2020.00894 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32595511

  2. Dupont, B (2001). [Choice and use of antifungal drugs]. La Revue du praticien 51(7) 752–757. PUBMED:https://pubmed.ncbi.nlm.nih.gov/11387672

  3. Hayashi, Y, et al., & Yamada, Y (1995). [Study of serial bronchoalveolar lavage in patients with aspergilloma: cell reaction at the affected sites and penetration of miconazole and flucytosine into the lesion]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 69(5) 517–523. DOI:10.11150/kansenshogakuzasshi1970.69.517 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7602184

Revisions


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