.Pharmacolibrary.Drugs.ATC.J.J04BA50 .Pharmacolibrary.Drugs.ATC.J.J04BA50| name: | DapsoneAndRifampicin | |
| ATC code: | J04BA50 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 1.5 | L |
| clearance: | 0.8 | L/h/kg |
| other parameters in model implementation | ||
Dapsone and rifampicin are antibacterial drugs used in combination as part of multidrug therapy for the treatment of leprosy (Hansen's disease). Dapsone is a sulfone antibiotic with bacteriostatic effects, while rifampicin is a rifamycin antibiotic with potent bactericidal action against Mycobacterium leprae. This combination remains standard of care for leprosy and is still in use today.
Estimated pharmacokinetic parameters for typical adult patients (sex unspecified) treated for leprosy, as PK data on the fixed combination are not directly available in the literature; parameters based on monotherapy data for dapsone and rifampicin.