.Pharmacolibrary.Drugs.ATC.J.J05AB06_2

Information

Ganciclovir is an antiviral medication used mainly to prevent and treat cytomegalovirus (CMV) infections, notably in immunocompromised individuals, such as those with HIV/AIDS, organ transplant, or undergoing chemotherapy.

Pharmacokinetics

Following oral administration (as valganciclovir, ganciclovir prodrug), healthy adults.

References

1. Nguyen, T, et al., & Hirt, D (2021). Population Pharmacokinetics of Intravenous Ganciclovir and Oral Valganciclovir in a Pediatric Population To Optimize Dosing Regimens. Antimicrobial agents and chemotherapy 65(3) –. DOI:10.1128/AAC.02254-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33318012

2. Perrottet, N, et al., & Buclin, T (2009). Population pharmacokinetics of ganciclovir in solid-organ transplant recipients receiving oral valganciclovir. Antimicrobial agents and chemotherapy 53(7) 3017–3023. DOI:10.1128/AAC.00836-08 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19307355

3. Caldés, A, et al., & Grinyó, JM (2009). Population pharmacokinetics of ganciclovir after intravenous ganciclovir and oral valganciclovir administration in solid organ transplant patients infected with cytomegalovirus. Antimicrobial agents and chemotherapy 53(11) 4816–4824. DOI:10.1128/AAC.00085-09 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19738014

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)