.Pharmacolibrary.Drugs.ATC.J.J05AE07

Information

name:Fosamprenavir
ATC code:J05AE07
route:oral
n-compartments2

Fosamprenavir is a prodrug of amprenavir, a protease inhibitor used as an antiretroviral agent in the treatment of HIV-1 infection. Fosamprenavir is hydrolyzed to amprenavir after oral administration and, when used in combination with other antiretrovirals, reduces viral load and improves immune function. It is approved by health authorities including the FDA, primarily for adults and children over four years old.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects after a single oral dose of 1400 mg fosamprenavir without ritonavir coadministration.

References

  1. Barbour, AM, et al., & Wire, MB (2014). Population pharmacokinetic modeling and simulation of amprenavir following fosamprenavir/ritonavir administration for dose optimization in HIV infected pediatric patients. Journal of clinical pharmacology 54(2) 206–214. DOI:10.1002/jcph.205 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25272370

  2. Dolton, MJ, et al., & McLachlan, AJ (2014). Understanding variability in posaconazole exposure using an integrated population pharmacokinetic analysis. Antimicrobial agents and chemotherapy 58(11) 6879–6885. DOI:10.1128/AAC.03777-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25199779

Revisions


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